CBD Reduces Brain Damage in a Rat Model of Neonatal Arterial Ischemic Stroke

Neonatal Arterial Ischemic Stroke, or Neonatal AIS, refers to a lack of blood flow to certain parts of a newborn child’s brain due to the narrowing of an artery or a blood clot in an artery. According to The International Pediatric Stroke Study, “Neonatal AIS has emerged as a leading cause of perinatal brain injury, cerebral palsy and lifelong disability.” (1) Unfortunately, there is currently no known effective treatment.

In April 2017, European researchers published a study in the Journal of Neuropharmacology that demonstrated the neuroprotective effect of CBD in a rat model of AIS. According to the scientists performing the study, CBD administration led to:

  • long-term functional recovery
  • reduced neuronal loss
  • reduced astrogliosis, which is an abnormal increase in the number of astrocytes due to the destruction of nearby neurons
  • modulation of apoptosis (death of cells), metabolic derangement, excitotoxicity and neuro-inflammation
  • improved neurobehavioral function regarding strength, hemiparesis (weakness or the inability to move one side of the body), coordination and sensorimotor performance

Given there is no current treatment for this serious and life altering type of childhood stroke, the results of this study are extremely promising and warrant deeper investigation into CBD for its neurological health benefits. You can learn more about this study at: https://www.ncbi.nlm.nih.gov/pubmed/28012949.