There were four RCTs highlighted in this study that involved treatment with CBD. The results from these four studies demonstrated that there was no statistically significant difference between CBD and the placebo in seizure freedom, quality of life, sleep disruption, or vomiting. There was, however, a statistically significant difference in reduction of medium frequency of monthly seizures, an increase in the number of participants with at least a 50% reduction in seizures and frequent diarrhea. Death and status epilepticus were infrequently reported.
By looking at these studies as a whole the researchers stated with moderate certainty that CBD reduces seizures among children with drug-resistant epilepsy. Patients are cautioned, however, that this study focuses only on CBD and should not be extended to all cannabis products.
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