In-Vitro Study Shows Anti-inflammatory Properties of CBD for Allergic Contact Dermatitis

CBD was shown to elevate levels of anandamide, resulting in anti-inflammatory and anti-allergenic properties.

Dermatitis is a common problem with a wide range of causes; it involves excessive pro-inflammatory compounds in the skin, often resulting in an itchy rash or red swollen skin. Allergic Contact Dermatitis (ACD) involves the immune system overreacting to certain substances, sometimes even in very small amounts, that normally shouldn’t cause a reaction. Some of the most common examples are:

  • Dander from dogs, cats and other animals
  • Plant oils and compounds such as poison ivy and latex
  • Certain metals such as nickel and gold, often found in jewelry
  • Fragrances found in body and home products such as perfumes, deodorants, shampoos and cleaning products
  • Topical antibiotics common in first aid creams and ointments
  • Preservatives such as Quaternium 15, frequently found in cosmetic and industrial products

In June of 2018, research scientists created an in-vitro (meaning it was performed outside of a living organism, such as in a test tube or culture dish) model of ACD and measured the release of pro-inflammatory compounds in the presence of CBD and other phytocannabinoids. Based on their findings, CBD was shown to elevate levels of anandamide, an endogenous cannabinoid that activates CB2 receptors (such as along immune cells in the blood), resulting in anti-inflammatory and anti-allergenic properties. It was also shown to have no cytotoxic effect.

This study is very promising and warrants deeper investigation of topical CBD on humans and animals for relieving the symptoms of ACD. You can learn more about the study, found in the Journal of Pharmacology and Experimental Therapeutics, at: http://jpet.aspetjournals.org/content/365/3/652.

Article by:

Tristan Summerfield, Nutritionist and Herbalist
Nectar CBD National Sales and Education
sales@coloradowholesalecompany.com
719.345.2500 x2

I have been a natural health educator since 2007 and my passion is helping people and the Planet to thrive using time-tested and scientifically verified foods, herbs, medicinal mushrooms, and sustainable lifestyle practices. If you have a US-based health business for humans or animals, please contact me and I can give you more details and samples of our 100% organic, full-spectrum, Colorado-grown, hemp-CBD products!

CBD Could Help Treat Diabetic Retinopathy

In a study performed by the Department of Pharmacology and Toxicology at the Medical College of Georgia, researchers studied the protective effects of cannabidiol (CBD) on rats with diabetic retinopathy.

One of the many complications of diabetes can be diabetic retinopathy.  Caused by damage to the blood vessels in the retina of the eye, diabetic retinopathy impairs eyesight and can possibly lead to blindness. In a study performed by the Department of Pharmacology and Toxicology at the Medical College of Georgia, researchers studied the protective effects of cannabidiol (CBD) on rats with diabetic retinopathy.  CBD is one of the main components of hemp and has been shown to have a regulatory effect on the body’s endocannabinoid system, as well as, a diverse pharmacological profile.

During the conducted study, rats were induced with diabetes and treated with CBD after 1, 2 or 4 weeks. The diabetes caused significant rises in oxidative stress, retinal neuronal cell death and vascular permeability; following CBD treatment, these symptoms were reduced. The CBD administered also prevented retinal cell death and vascular hyperpermeability, which is excessive leaking of fluid and proteins from the blood vessels. The combined results demonstrated that CBD could reduce neurotoxicity, inflammation and blood-retinal barrier breakdown in diabetic animals.

We look forward to reviewing more medical studies regarding CBD therapy and diabetes.  To read the study from the Medical College of Georgia, referenced above, please see here.

UK Study Shows CBD Can be Used as a Cardioprotectant

The study clearly demonstrated the cardioprotective properties of CBD in the acute phase of I/R injuries due to the fact it both reduced ventricular arrhythmias and reduced infarct sizes.

Cannabidiol (CBD) has proven to have anti-apoptotic, anti-inflammatory and antioxidant effects within its diverse pharmacological profile.  As one of the main non-psychotropic components of hemp, CBD has been gaining popularity in recent years. Researchers have been exploring the effects of CBD on various diseases and health conditions, often with surprisingly positive results.  One such study tested the theory that cannabidiol would benefit those struggling with myocardial ischaemia and reperfusion. Also known as I/R, the cardiovascular condition is caused by constricting arteries which limit blood flow to the heart, ischaemia, and the resulting tissue injury that can occur when blood flow returns, reperfusion.  Inflammation and oxidative stress are common with I/R, making CBD a possible treatment worth investigating.

Researchers at the School of Pharmacy and Life Sciences at the Institute for Health and Welfare Research at Robert Gordon University, in the United Kingdom, performed a study to test the hypothesis that cannabidiol could act as a cardioprotectant in the acute phase of an I/R injury.  Rats treated with CBD ten minutes prior to both coronary artery occlusion and reperfusion were compared to rats who received only a placebo.  Arterial blood was also withdrawn at the end of the reperfusion period to study.  Rats who received CBD had a reduced number of ischaemia-induced arrhythmias, as well as, reduced infarct, which are localized areas of dead tissue caused by loss of blood flow.  The researchers concluded that the study clearly demonstrated cardioprotective properties of CBD in the acute phase of I/R injuries due to the fact it both reduced ventricular arrhythmias and reduced infarct sizes.

We are eager to review more research which demonstrates how cannabidiol can be beneficial to those struggling with cardiovascular disorders.  To read more about the study mentioned above, please click here.

CBD Could be a New Treatment Therapy for MS, According to New Study

Neuroscientists conducted a study to examine the potential effects of cannabidiol on the PI3K/AKT/m/TOR pathway.

Multiple Sclerosis, or MS, is a chronic disease in which damage occurs to the sheaths of nerve cells in the brain and spinal cord. Often a progressive disease, symptoms can include pain, numbness, speech impairment and fatigue. Researchers have begun to study cannabidiol (CBD) as a possible treatment therapy, as CBD is one of the many compounds found in hemp and has a diverse pharmacological profile with little to no adverse side effects.

The PI3K/AKT/m/TOR pathway, an intracellular signaling pathway which regulates cell cycles, has become of interest to researchers studying MS, as it plays a major part in cellular quiescence, proliferation, cancer and longevity. Neuroscientists at the Contrada Casazza, in Italy, conducted a study in 2017 to examine the potential effects of cannabidiol on the PI3K/AKT/m/TOR pathway.

In their study, researchers induced mice with the most common model of MS.  After the disease symptoms began, the mice were treated with CBD at a rate of 10mg/kg of body weight daily and observed for clinical signs of MS.  After 28 days, the mice were euthanized and spinal tissues were sampled.  The results demonstrated a clear downregulation of the PI3K/AKT/m/TOR pathway and that CBD was effectively able to restore it.  Their data demonstrated the therapeutic efficacy of CBD, due to the reduction of pro-inflammatory cytokines and the promotion of cell neuron survival.  They concluded their study by stating that the, “results provide an interesting discovery about the regulation of the PI3K/AKT/m/TOR pathway by cannabidiol administration, that could be a new potential therapeutic target for MS management.”

This is exciting news for Multiple Sclerosis patients. We hope research will continue to investigate how CBD can regulate the PI3K/AKT/m/TOR pathway and how it could benefit those suffering from MS. To learn more about the study referenced above, click here.

CBD Could Offer Neuroprotection for Newborn Infants

This study recognizes the important role of CBD in treating neonatal HI injuries, in addition to, protecting newborns from long-term brain damage.

When babies are born unable to breathe properly, they can develop hypoxia-ischemia (HI), a condition which occurs when the brain doesn’t receive enough oxygen.  HI may cause long-term side effects, including brain damage, of varying severity.  With limited treatment options available to premature newborn and babies, researchers have been searching for an effective method to protect delicate brain cells.  Cannabidiol (CBD), a non-psychoactive cannabinoid, or chemical component of the hemp plant, has previously demonstrated short-term neuroprotective properties on the brain, following a HI injury, during clinical studies.

As a follow-up to previous studies, researchers at the Foundation for Biomedical Research in Madrid, Spain, examined the neuroprotective effects of CBD and if those effects were sustainable long-term.  Newborn rats sustained a HI injury, with some receiving CBD treatment alongside non-treated rats.  After 30 days, the rats were subjected to magnetic resonance imaging, histological evaluation, magnetic resonance spectroscopy and Western blotting to evaluate whether the CBD treatments had any lasting effects on the brain tissue. Their results showed that CBD effectively modulated brain excitotoxicity, oxidative stress and inflammation.  This study recognizes the important role of CBD in treating neonatal HI injuries, in addition to, protecting newborns from long-term brain damage.

To read more about the aforementioned study, please click here.

CBD Could Protect Kidneys During Cisplatin Chemotherapy

By using its ability to regulate the bodies’ endocannabinoid system, CBD has shown to not only protect against cancer, but also able to treat the side effects from other cancer treatments, such as cisplatin-induced nephrotoxicity.

Cannabidiol, or CBD, has received significant attention due to clinical research findings that it may treat certain types of cancer.  Other research has shown CBD to be an effective cancer therapy treatment, with benefits such as anti-nausea, increase of appetite and pain management.  One of the most potent chemotherapies used to treat cancer, cisplatin, can cause significant stress to the body; one of these side effects is nephrotoxicity, which negatively effects the renal function of kidneys. Nephrotoxicity can be so severe, from the cisplatin, that it is limited in clinical use.

To find a way to counteract the nephrotoxicity caused by cisplatin, with hopes of making it more available to patients in need, researchers at Zhejiang University, in China, studied the effects of cannabidiol when combined with cisplatin.  Mice treated with cisplatin showed inflammation of the kidneys and impaired renal function (among other side-effects) after only 72 hours.  Cisplatin-treated mice, that were administered CBD, reported reduced oxidative/nitrosative stress, inflammation and cell death within the kidney, as well as, improved renal function.  The researchers concluded that cannabidiol may offer a protective strategy against cisplatin-induced nephrotoxicity.

By using its ability to regulate the bodies’ endocannabinoid system, CBD has shown to not only protect against cancer, but also able to treat the side effects induced from cancer treatments, such as the case above, where CBD protected kidneys from nephrotoxicity during chemotherapy.

To read more about the study mentioned above, please click here.

Australian Study Looks at CBD as Possible Preventative Treatment for Alzheimer’s Disease

The untreated AD mice demonstrated a social recognition deficit, which was not apparent in the CBD-treated AD mice.  Researchers stated that their “findings provide the first evidence that CBD may have potential as a preventative treatment for AD with a particular relevance for symptoms of social withdrawal and facial recognition.”

Alzheimer’s Disease (AD) is a devastating disease not only for those diagnosed, but also for their families.  There is currently no cure for AD.  Brain cell connections slowly degenerate and die, destroying memory and other important mental functions.  As the disease progresses, patients lose the ability to recognize friends and family, short and/or long-term memory and even the ability to remember how to perform simple tasks; it is a terrifying journey for those suffering, as it is for those closest to them.

Cannabidiol, or CBD, has been proven to have neuroprotective, anti-oxidative and anti-inflammatory properties.  Previous studies have shown CBD treatment can reverse Alzheimer’s Disease’s cognitive deficits in mice, both in vitro and in vivo.  Those exciting results have prompted further research to evaluate the effects of CBD on Alzheimer’s Disease.

Neuroscientists of Australia’s School of Medical Sciences conducted a study in 2014 to study the effects of CBD at preventing Alzheimer’s Disease symptoms in mice.  AD mice were treated with CBD daily from 2.5 months of age until 8 months.  The CBD-treated AD mice and untreated AD mice were then evaluated on a series of tests such as social preferences, mazes and recognition.  The untreated AD mice demonstrated a social recognition deficit, which was not apparent in the CBD-treated AD mice.  Researchers stated that their “findings provide the first evidence that CBD may have potential as a preventative treatment for AD with a particular relevance for symptoms of social withdrawal and facial recognition.” The neuroscientists also noted that the CBD-treated mice showed reduced neuroinflammation, cholesterol and dietary phytosterol retention, which may trigger separate studies to further investigate other possible benefits of CBD therapy.

The possibility of preventing the onset or advancement of Alzheimer’s Disease is certainly exciting for both the medical community and those living with the disease.  To review the study discussed above, please see the link here.

CBD Reduces the Occurrence of Diabetes in Mice

CBD therapy reduced the occurrence of diabetes in mice from 86% to only 30%.

Over 30 million people in the U.S. alone are currently managing diabetes. With astronomical health care costs and inconvenient treatment options, the number of people seeking alternate treatment options continues to increase every year.  Cannabidiol (CBD), a nonpsychoactive cannabinoid found in hemp, has been proven to effectively regulate the endocannabinoid system (ECS), which influences diabetes‐induced oxidative stress, inflammation, fibrosis and subsequent tissue injury in target organs for diabetic complications. As a result, researchers have begun to study how CBD could help manage or treat diabetes.

As early as 2006, scientists at the Hadassah University Hospital, in Jerusalem, Israel, examined the effects cannabidiol had on suppressing diabetes in mice.  The results were astounding: CBD therapy reduced the occurrence of diabetes in mice from 86% to only 30%.  CBD treatment also reduced the levels of pro-inflammatory Th1-associated cytokines, while increasing beneficial Th2-associated cytokines.  Examination on the pancreatic islets of the CBD treated mice also showed significantly reduced insulitis, when compared to mice who had not received treatment.  They concluded that CBD was effective at inhibiting and delaying insulitis and inflammatory Th1-associated cytokine production in mice.

While knowledge of how CBD can benefit those suffering from diabetes is ongoing, individuals are attesting that CBD has become a significant part of their diabetes treatment plan.  CBD is a natural, well-tolerated treatment therapy which would make it a very appealing option for those struggling to manage their diabetes.

To read more about the study at the Hadassah University Hospital, please click here.

Research Shows CBD Could Treat Cardiovascular Disorders

For those suffering from cardiovascular disorders, CBD could offer a natural treatment therapy, as opposed to, pharmaceutical or surgical options.

Millions of people are affected each year by a multitude of cardiovascular disorders.  With a direct connection to the heart, they are some of the most severe health complications one can undergo.  Doctors and scientists, in an effort to find improved, effective treatment options, have conducted research on how CBD, or cannabidiol, could possibly treat different types of cardiovascular disorders. Cannabidiol is one of the most abundant compounds found in hemp and has shown promising anti-inflammatory, pain-relieving and seizure-reducing properties.

A team of researchers at the National Institute on Alcohol Abuse and Alcoholism, at the National Institute of Health, in Maryland, studied the effects of cannabidiol on myocardial dysfunction, inflammation, oxidative/nitrative stress, cell death and interrelated signaling pathways, all of which are varying indicators of cardiovascular dysfunction.  Using a mouse model of type I diabetic cardiomyopathy and human cardiomyocytes, mice were exposed to high glucose, allowing researchers to study the effects CBD on the pressure-volume system. Their findings showed that CBD therapy was able to weaken the effects of myocardial dysfunction, cardiac fibrosis, oxidative stress and inflammation.  The study abstract concludes that, “Collectively, these results coupled with the excellent safety and tolerability profile of CBD in humans, strongly suggest that it may have great therapeutic potential in the treatment of diabetic complications, and perhaps other cardiovascular disorders, by attenuating oxidative/nitrative stress, inflammation, cell death and fibrosis.”

Research, such as the work being done at the National Institute of Health, highlights how effective CBD could be for a vast array of health issues.  For those suffering from cardiovascular disorders, CBD could offer a natural treatment therapy, as opposed to, pharmaceutical or surgical options.

To read more about the study quoted above, please click here.

Preliminary Research Claims CBD Could Help Treat Acne

Combined with its anti-inflammatory properties, findings suggest that CBD could be a promising treatment for those suffering from acne.

Cannabidiol, or CBD, has the ability to regulate the endocannabinoid system which controls multiple physiological processes.  Along with being a known anti-inflammatory, researchers are continuously learning more about the pharmacological profile of this natural plant compound and its potential applications; one such study examined how CBD could help those suffering from acne.

In 2014, researchers studied the effects of cannabidiol on human sebaceous (secretion) glands. Their findings showed that CBD has a highly effective sebostatic effect, reducing skin oil production.  When CBD was applied to cultures of human skin and sebocytes, it inhibited the lipogenic effects of other compounds.  Combined with its anti-inflammatory properties, their findings suggest that CBD could be a promising treatment for those suffering from acne.

Millions of individuals struggle with persistent, unwanted acne and often resort to treating it with caustic chemical formulations.  We look forward to more research on how CBD may be used for as an effective acne treatment.

To read more on the study referenced above, click here.