Effects of CBD on Muscle Quality and Performance in Mice with Muscular Dystrophy

Researchers test CBD’s ability to restore functional autophagy, reduce inflammation and positively enhance muscle function.

Italian researchers sought to determine if CBD would demonstrate any effect on Duchenne muscular dystrophy (DMD). DMD is a genetic disorder characterized by progressive muscle degeneration and weakness; it is one of nine types of muscular dystrophy. Prior research has determined that autophagy, the natural destruction of cells, greatly contributes to the aggravation of muscle damage. Researchers tested CBD’s ability to restore functional autophagy, reduce inflammation and positively enhance muscle function.

During the study, mice with DMD were injected with CBD at different stages of the disease. After treatment, locomotor tests and biochemical analyses were used to evaluate their effects on inflammation and autophagy. Researchers also observed the interaction of CBD with transient receptor potential (TRP) channels; these channels respond to different stimuli, including pain. At the conclusion of the study, researchers determined that the administered CBD prevented the loss of locomotor activity, reduced inflammation and restored autophagy. The mice also had rapid desensitization in the TRP channels, allowing the mice to feel less pain. Overall the researchers are optimistic in utilizing CBD, in conjunction with traditional treatments, to treat DMD and provide patients with a better quality of life through reduced inflammation, restored functional autophagy and improved muscle function.

To review the medical study abstract, please click here.

Dogs with Osteoarthritis Treated with CBD have Increased Comfort and Activity

The study concluded that administering CBD oil to dogs with osteoarthritis increased both comfort and activity.

A collection of veterinary hospitals and clinics conducted a study to determine the effect of CBD oil, administered twice daily, on dogs with osteoarthritis.

The dogs in this study were split into three groups, receiving CBD oil at 2mg/kg, 8 mg/kg or placebo oil every 12 hours; their treatments continued for 4 weeks. During this trial period the dog owners completed surveys and the dogs had veterinary assessments before treatment, at 2 weeks and at 4 weeks, upon conclusion of the study. Blood work, serum chemistry and physical examinations were also performed at each veterinary visit to assess how their bodies were processing the oil.

At the conclusion of the study, the owner’s survey and the veterinary assessments noted that there was a decrease in pain and an increase in activity during the CBD treatment with no observable side effects. However, serum chemistry showed an increase in alkaline phosphatase while taking CBD which could eventually affect the kidneys. Overall, this study concluded that administering CBD oil to dogs with osteoarthritis increased both comfort and activity.

To learn more about this study please click here.

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CBDA Beneficial for Pain and Inflammation in a Rodent Model of Inflammatory Pain

Cannabis has shown to have anti-inflammatory and anti-hyperalgesia (lowering of pain response) properties, but the exact plant components causing these effects were the target of this study.

A recent study from the Department of Psychology and Collaborative Neuroscience Program at the University of Guelph in Ontario, Canada, has examined the pain reducing and anti-inflammatory properties of chemical components, called cannabinoids, in cannabis.  Specifically, CBD, CBDA (CBD’s acidic precursor, cannabidiolic acid) and THC were studied in an animal model of acute inflammation, in the paw of a rat.  Cannabis has shown to have anti-inflammatory and anti-hyperalgesia (lowering of pain response) properties, but the exact plant components causing these effects were the target of this study.

Researcher results demonstrated that CBDA was the most effective at relieving both pain and inflammation when administered intraperitonially 60 minutes prior to carrageenan-induced inflammation.  Both CBDA and THC given orally had anti-hyperalgesia effects, and the THC also reduced inflammation.  Comparatively, equal dosage of CBD did not display the same pain-relieving results, which led researchers to conclude that CBDA is more effective for this application.  Interestingly, when very low doses of CBDA and THC were not effective on their own, when combined, they produced anti-hyperalgesia effects, along with, reduced inflammation.

This study was able to importantly identify the effects of different components of the cannabis plant and the medicinal properties they possess.  While CBD was not the most effective at managing pain and inflammation in this study, a different cannabinoid, CBDA, was extremely effective.  CBDA can be found in many CBD-rich products such as tinctures, topicals and edibles.

To read more about the aforementioned study from the University of Guelph, click here.

Neuropathic Chronic Pain Conditions May Benefit from CBD

A group of researchers from the United States, Canada and Italy conducted a study on rats to determine if CBD could be a viable treatment option for neuropathic pain conditions.

Previous clinical studies have demonstrated that cannabidiol (CBD) may be effective at relieving pain while also possessing anti-anxiety effects.  Cannabidiol is one of the main non-psychoactive components of the hemp plant.  While the analgesic and anxiolytic effects of CBD have been widely studied, its effect on serotonin neuronal cell activity, and its impact on models of neuropathic chronic pain, are unknown.  A group of researchers from the United States, Canada and Italy conducted a study on rats to determine if CBD could be a viable treatment option for neuropathic pain conditions.

Using in-vivo single-unit extracellular recordings in rats, researchers demonstrated that slowly increasing low doses of CBD decreased the firing rate of serotonin neurons in the dorsal raphe nucleus, the part of the brain stem that contains the majority of serotonin and is linked to stress and emotional processing.  Repeated injections of CBD for 7 days, in conjunction with the stimulation of heat receptors, increased serotonin firing through the desensitization of serotonin receptors.

Rats were then subjected to a nerve injury model to induce mechanical allodynia, a nerve condition in which a normal stimulus, such as the touch of clothing, causes debilitating pain. The test subjects were subjected to the nerve injury for 24 days and showed decreased serotonin firing activity, mechanical allodynia and increased anxiety-like behavior during maze tests, open-field tests and novelty-suppressed feeding tests. The subjected rats were then treated with CBD for seven days which reduced mechanical allodynia, decreased anxiety-like behavior and normalized serotonin activity. The study concluded that the repeated low-dose treatments of CBD effectively reduced pain by heat receptor activation and reduced anxiety through serotonin receptor activation.

While more research and trials are required to study this area further, this initial study demonstrates that patients suffering from neuropathic chronic pain conditions could possibly benefit from CBD.  To learn more about this study, please click here. https://www.ncbi.nlm.nih.gov/pubmed/30157131

CBD Could be an Effective Immunosuppressant for MS Treatment

CBD has previously demonstrated immunosuppressant properties which encouraged a new study examining the effectiveness of CBD as a treatment therapy option for MS patients.

Multiple Sclerosis, often referred to as MS, is a disease which causes the body’s immune system to attack and destroy the protective covering of nerves. Once this covering, called myelin, is degraded, the nerve fibers begin to disintegrate which often leads to severe physical debilitation.

One of the most effective treatment therapies for MS is the use of immunosuppressant drugs. Glatiramer acetate (Copaxone) is one such drug currently in clinical use.  Cannabidiol, one of the main non-psychoactive compounds found in the cannabis plant (often referred to as CBD), has previously demonstrated immunosuppressant properties which encouraged a new study examining the effectiveness of CBD as a treatment therapy option for MS patients.

Researchers at the Hadassah Medical School at The Hebrew University of Jerusalem compared the effectiveness of CBD and the cannabis indica subspecies known as Avidekel with Copaxone.  Avidekel is known for its extremely high CBD content, paired with very low amounts of THC. The data from their research demonstrated that the Avidekel extract and CBD were as effective as Copaxone at alleviating MS symptoms in mice and acted as an immunosuppressant.

While more research and clinical trials are required, preliminary data suggests that CBD could be a viable treatment therapy option for multiple sclerosis.  Unlike Copaxone, CBD does not have to be injected, which could result in fewer doctor visits and is a readily available all-natural product.  To buy cbd rich hemp oil and organic cbd hemp oil, visit our website at www.BuyNectarCBD.com.

To read more about the aforementioned study, please follow this link.

The Most Effective Delivery Method of CBD for Dogs

A study by Colorado State University sought to determine the pharmacokinetics of cannabidiol (CBD) in dogs.

A study performed by the Department of Clinical Sciences at Colorado State University sought to determine the pharmacokinetics of cannabidiol (CBD) in dogs. Pharmacokinetics examines the bodily absorption, distribution, metabolism and excretion of drugs.

The study performed involved the participation of 30 healthy dogs. Each dog was treated with one of three CBD treatments: oral CBD oil beads, oral CBD oil or CBD skin cream. The dosages were 75mg or 150mg every 12 hours for 6 weeks, with the CBD treatments being dose-proportional. Cannabidiol levels in the dogs’ blood were measured over the course of the 6-week study. The experiment demonstrated that that oral dosages of CBD oil had the best pharmacokinetic profile, as this delivery method demonstrated the highest concentrations of cannabidiol retention in the dogs’ system.

To learn more about the Colorado State University canine study referenced above, please see the link here.

Nectar CBD offers CBD-rich hemp oil pet drops, Nectar 300 Pet Drops and Nectar 600 Pet Drops, which are hemp extract formulated in organic MCT coconut oil. Nectar CBD provides organic CBD oil for sale in Colorado and offers an entire line of CBD products for pets, including pet treats.

Study Shows Cannabidiol Inhibits Lung Cancer Cell Invasion

CBD could help stop the spread of cancer cells in the lungs and support lung function in general.

Focusing on the health of our lungs is often a neglected practice, and yet, according to the American Lung Association, approximately 415,000 Americans living today have been diagnosed with lung cancer. Lung cancer is the most common cancer worldwide, accounting for 1.8 million new cases and 1.6 million deaths in 2012 (1). The search for natural remedies to prevent and combat cancer cells in the lungs has led to research on the potential beneficial properties of CBD.

In 2009, the work of researchers studying the effect of cannabinoids against cancer cell invasion was published in the Federation of American Societies for Experimental Biology. Their results showed that cannabidiol upregulated a compound called ICAM-1 in a clinically significant manner, which then led to a subsequent decrease in cancer cell invasiveness.

Given that lung cancer is the most common cancer worldwide and that sufficient oxygen flow is a key factor for producing cellular energy, this study becomes extremely promising and warrants deeper study into how CBD can help stop the spread of cancer cells in the lungs and support lung function in general. You can learn more about this study at: https://www.ncbi.nlm.nih.gov/pubmed/22198381.

In-Vivo Study Demonstrates CBD Protects Against Heart Tissue Injury

CBD was able to prevent further tissue damage and allow the tissue to regenerate and heal faster.

Heart tissue injury most commonly results from severe impairment of coronary blood supply and is a major cause of death and disability worldwide. Current therapies can, in themselves, induce further damage and death. Luckily, a number of new therapeutic strategies are currently under investigation for preventing heart tissue injury and one of the most promising is CBD or cannabidiol.

In 2009, The American Journal of Physiology published the results of researchers who tested the effect of CBD on injured rat hearts. According to the researchers, “Our study shows that CBD induces a substantial in vivo cardioprotective effect from ischemia that is not observed ex vivo. Inasmuch as CBD has previously been administered to humans without causing side effects, it may represent a promising novel treatment for myocardial ischemia.” In addition, researchers found that CBD-treated animals were associated with reduced heart tissue inflammation; this may be one of the main underlying reasons as to why CBD was able to prevent further tissue damage and allow the tissue to regenerate and heal faster.

Given that Coronary Heart Disease (CHD) is the leading cause of death and disability worldwide and is often attributable to the detrimental effects of acute heart tissue injury, this study warrants a human study of the protective effects of CBD. You can learn more about this study at: https://www.ncbi.nlm.nih.gov/pubmed/17890433.

 

In-Vitro Study Shows Anti-inflammatory Properties of CBD for Allergic Contact Dermatitis

CBD was shown to elevate levels of anandamide, resulting in anti-inflammatory and anti-allergenic properties.

Dermatitis is a common problem with a wide range of causes; it involves excessive pro-inflammatory compounds in the skin, often resulting in an itchy rash or red swollen skin. Allergic Contact Dermatitis (ACD) involves the immune system overreacting to certain substances, sometimes even in very small amounts, that normally shouldn’t cause a reaction. Some of the most common examples are:

  • Dander from dogs, cats and other animals
  • Plant oils and compounds such as poison ivy and latex
  • Certain metals such as nickel and gold, often found in jewelry
  • Fragrances found in body and home products such as perfumes, deodorants, shampoos and cleaning products
  • Topical antibiotics common in first aid creams and ointments
  • Preservatives such as Quaternium 15, frequently found in cosmetic and industrial products

In June of 2018, research scientists created an in-vitro (meaning it was performed outside of a living organism, such as in a test tube or culture dish) model of ACD and measured the release of pro-inflammatory compounds in the presence of CBD and other phytocannabinoids. Based on their findings, CBD was shown to elevate levels of anandamide, an endogenous cannabinoid that activates CB2 receptors (such as along immune cells in the blood), resulting in anti-inflammatory and anti-allergenic properties. It was also shown to have no cytotoxic effect.

This study is very promising and warrants deeper investigation of topical CBD on humans and animals for relieving the symptoms of ACD. You can learn more about the study, found in the Journal of Pharmacology and Experimental Therapeutics, at: http://jpet.aspetjournals.org/content/365/3/652.

CBD Could Help Treat Diabetic Retinopathy

In a study performed by the Department of Pharmacology and Toxicology at the Medical College of Georgia, researchers studied the protective effects of cannabidiol (CBD) on rats with diabetic retinopathy.

One of the many complications of diabetes can be diabetic retinopathy.  Caused by damage to the blood vessels in the retina of the eye, diabetic retinopathy impairs eyesight and can possibly lead to blindness. In a study performed by the Department of Pharmacology and Toxicology at the Medical College of Georgia, researchers studied the protective effects of cannabidiol (CBD) on rats with diabetic retinopathy.  CBD is one of the main components of hemp and has been shown to have a regulatory effect on the body’s endocannabinoid system, as well as, a diverse pharmacological profile.

During the conducted study, rats were induced with diabetes and treated with CBD after 1, 2 or 4 weeks. The diabetes caused significant rises in oxidative stress, retinal neuronal cell death and vascular permeability; following CBD treatment, these symptoms were reduced. The CBD administered also prevented retinal cell death and vascular hyperpermeability, which is excessive leaking of fluid and proteins from the blood vessels. The combined results demonstrated that CBD could reduce neurotoxicity, inflammation and blood-retinal barrier breakdown in diabetic animals.

We look forward to reviewing more medical studies regarding CBD therapy and diabetes.  To read the study from the Medical College of Georgia, referenced above, please see here.